Information Library

Major universities and teaching hospitals throughout the U.S., Europe, Australia and Asia have performed over 140,000 scientific studies with Beta Glucan. Over 10,000 of these studies have been published. All validate the safety and many benefits of Beta Glucan. You can explore some of these studies below.

If you are interested in one specific category/topic (white text with grey background), you can click on it and it will show all the studies listed with the category/topic that you selected.

Additional studies, videos, etc., is available at A.J. Lanigan’s informational website, http://vitawithimmunity.com

Explore the articles below for research information concerning verious topics and conditions in which Beta Glucan 1,3D has been shown to help.

Comparison of Glucans

A Comparison of Injected and Orally Administered β-glucans

JANA Vol. 11, No. 1, 2008 — Article shows A.J. Lanigan’s Beta 1, 3-D Glucan is the best absorbed and longest lasting of the other products tested.  Read more...

ChemotherapyGlucanlung cancer

A Randomized, Open-Label, Multicenter, Phase II Study Evaluating the Efficacy and Safety of BTH1677 (1,3–1,6 Beta Glucan; Imprime PGG) In Combination with Cetuximab and Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer.

Invest New Drugs 2017 - Thomas, M., Sadjadian, P., Kollmeier, J., Lowe, J., Mattson, P., Trout, J., . . . Schneller, F., III. (2017, March 1). A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3–1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer. Retrieved March 24, 2017, from Springedink.com. This article is about a Phase II study that was conducted with Beta 1,3-1,6 Glucan being used in conjunction with anti-tumor antibody therapies. Lung Cancer is the third most frequent type of Cancer, after Breast and Prostate Cancers. NSCLC, non-small cell lung cancer, makes up 85% of lung cancers. Traditionally it has been treated with chemotherapies. With increased research, Monoclonal Antibodies are now being used with a great deal of success. The combination therapy with BTH1677 (Beta Glucan; Imprine PGG) and cetuximab, was well tolerated by patients. Cetuximab was later not approved for advanced stages of NSCLC, but the combination has been successful with other Monoclonal antibodies.  Read more...

phagocytosisSelenium

Addition of Selenium Improves Immunomodulative Effects of Glucan

North American Journal of Medical Sciences 2016 Volume 8, Issue 2, February 2016 — Addition of Selenium Improves Immunomodulative Effects of Glucan. “Using two different murine models of cancer, we showed that the Selenium (Se)/glucan combination strongly suppressed the growth of cancer, mostly probably via stimulation of immunity. CONCLUSIONS:  A combination of glucan with Se offers superior stimulation of immunity and inhibition of cancer growth. …data confirmed that Se supplementation used concomitantly with a high-quality glucan can significantly improve its biological effects. Studies evaluating the exact biological mechanisms of action are currently in progress.” North American Journal of Medical Sciences, Feb 2016 Volume 8 Issue 2.  Read more...

Comparison of Glucans

An Evaluation of the Immunological Activities of Commercially Available β1, 3-Glucans

JANA 2007 — Article ranks A.J. Lanigan’s Beta 1, 3-D Glucan the highest biologically active immune modulator of the seven products tested. Several conclusions can be made: 1) Not all glucans are created equal; 2) some of the commercial glucans have surprisingly low activity; 3) most glucans differ in biological effects based on tested characteristics; and 4) for good results in immunomodulation, it is more imperative to find a glucan from a solid vendor who is able to back the claims with solid scientific data. Thinking about the biological source of glucan is much less important.  Read more...

Physical StressPurity

ANTI-STRESS ACTION OF SEVERAL ORALLY-GIVEN β-GLUCANS

Biomed Pap Med 2010 — Article ranks A.J. Lanigan’s highly purified Beta 1, 3-D Glucan more effective than the four other products tested in preventing and reversing the negative effects on the immune system caused by physical stress and cold stress.  Read more...

ImmunityphagocytosisVitamin C

Combination of Glucan, Resveratrol and Vitamin C Demonstrates Strong Anti-tumor Potential

Anticancer Research (34) 2014 — Article looks at the effects of 11 commonly used dietary supplements as immunomodulators. The only product with consistently high activity was glucan.  Read more...

Breast Cancerphagocytosis

Comparison of Immunological Effects of Commercially Available β-Glucans

Applied Scientific Reports 2014 — Article describes a new comparative study of 15 glucans and immune reactions. A.J. Lanigan’s was the most active sample. Immunological and biological effect (ck) of individual glucans were found to not be related to source and solubility.  Read more...

Comparison of Glucans

Comparison of Immunological Effects of Commercially Available β-Glucans: Part III

International Clinical Pathology Journal 2016 — “Comparison of Immunological Effects of Commercially Available β-Glucans: Part III “- International Clinical Pathology Journal- Volume 2 Issue 4 2016 – This research study is the third examination of 15 Beta Glucan products from different sources- mushrooms, barley, yeast and oat, that are available to the general public. The researchers looked again at Phagocytosis, nitrite oxide formation, IL-2 and IFN-γ formation, and added a lung cancer model. No clear relevance between the source used for isolation and biological effects was found. As before, the 15 individual glucans differed in biological effects based on tested characteristics, but Glucan #300 (A.J. Lanigan’s) again served as a benchmark in all the trials. So, highly purified and highly active glucans have strong and pleiotropic effects, but poorly defined glucans have only medium (if any) biological effects. Important for consumers and physicians to know!  See more...

Honey BeesVirus

Effect of 1,3-1,6 β—Glucan on Natural and Experimental Deformed Wing Virus Infection in Newly Emerged Honeybees (Apis mellifera ligustica)

PLOS ONE November 9, 2016 — “(Honey Bees) Effect of 1,3-1,6 β-Glucan on Natural and Experimental Deformed Wing Virus Infection in Newly Emerged Honeybees (Apis mellifera ligustica)”, PLoS One (11), November 2016. The loss of honeybee populations in the Western Hemisphere and the world will have devastating effects on agriculture, as they are key pollinators in many ecosystems. Deformed Wing Virus is one of the main contributors to the loss of honeybee colonies. This virus persists in the bee colony until the colony eventually collapses. A concomitant infection is often present with Varroa, a mite that supports the replication of the DWV to high titers, which suppresses the bees’ immune system. This study used Beta Glucan in several dosage sizes and in different populations of honeybees. The cohort groups were given the same treatments- no injection, injection of a high-copy number DWV suspension into the haemocel (experimental DWV infection) or injection of PBS into the haemocoel (physical injury). A group of control bees were fed a diet enriched with Beta Glucan and then they received the same treatments. The Beta Glucan group had significantly less bees infected, and their viral loads were lessened. Their survival rates were significantly better. This suggests that Beta Glucan may contribute to an increase in honeybee resistance to infections from viruses. PLOS ONE November 9, 2016.  Read more..

Diabetic RetinopathyLipid MetabolismObesityVitamin D

Effects of Glucan and Vitamin D Supplementation on Obesity and Lipid Metabolism in Diabetic Retinopathy

The Open Biochemistry Journal 2018 - Zavorkova, Martina, Vetvicka, Vaclav et al. “Effects of Glucan and Vitamin D Supplementation on Obesity and Lipid Metabolism in Diabetic Retinopathy.” The Open Biochemistry Journal, vol. 12, no. 1, 2018, pp. 36–45., doi:10.2174/1874091×01812010036. CONCLUSION: From our data, we concluded that glucan and vitamin D supplementation strongly influence lipid metabolism and have positive effects on human health.  See more...

Bone MarrowCancerIrradiation; Chemotherapy

Effects of Glucan on Bone Marrow

Annals of Translational Medicine Vol2, No2, 2014 — Article describes the extensive research that has been done on the effects of Glucan on bone marrow, specifically the restoration of lymphopenia and neutropenia. The idea of Glucan being as a radioprotectant from accidental irradiation or cancer treatments is also addressed. Read more...

ImmunityLymphocytesNatural Killer (NK) Cells

Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial

International Journal of Clinical and Experimental Medical Sciences 2016 — Our previous work was devoted to the possibility of positively influencing some immune mechanisms in patients suffering from cancer related fatigue. The relation between cancer and fatigue is well established as well as the positive effects of glucan treatment in both experimental and clinical models of cancer. The aims of this study were to evaluate the hypothesis that glucan supplementation might influence the NK cells in patients with cancer-related fatigue. This study clearly demonstrated the positive effects of short-term glucan supplementation on post-surgery and the rehabilitating phase of patients overcoming cancer disease.  Read more...

DetoxificationImmunityMercuryUranium (Depleted)

Effects of β-Glucan on Some Environmental Toxins: An Overview

Biomed Pap Med 2014 — Article supports that Glucan #300 can be used as a support in reducing the adverse effects of some environmental toxins, including mercury thimerosal and depleted uranium. Read more...

Strong Immune Responose

Enhancing Effects of New Biological Response Modifier B-1,3 Glucan Sulfate PS3 on Immune Reactions

Cancer Transl Med 2015 — Glucans and Cancer: Historical Perspective.  The fact that glucans elicit strong and positive immune responses is well‑established. Since the 1980s, we know that glucans stimulate hematopoiesis and are useful before and during radio‑and chemotherapy and during intoxication with heavy metals. In addition, recent years showed that glucans also influence homeostatic processes and can help to neutralize physical, mental, or environmental stress and can help in the treatment of chronic fatigue syndrome. Read more...

Diabetic RetinopathyLeptinVitamin D

Effects of β-glucan and Vitamin D Supplementation on Inflammatory Parameters in Patients with Diabetic Retinopathy

Journal of Dietary supplements 2018 - Richter, Josef, et al. “Effects of B-Glucan and Vitamin D Supplementation on Inflammatory Parameters in Patients with Diabetic Retinopathy.” Journal of Dietary Supplements, 2018, pp. 1–10., doi:10.1080/19390211.2018.1458769. Diabetes is a prevalent disease in the USA and the world. Almost 10% of Americans have or will have diabetes. Of those, 5% will get diabetic retinopathy, making it the most common cause of vision loss among people with diabetes and the leading cause of vision impairment and blindness among working-age adults. It is caused by damage to the blood vessels in the retina from several sources including poorly controlled blood sugar and inflammation. This study examined the effects of dosing with either Vitamin D plus beta glucan, Vitamin D alone, or Vitamin D and a placebo on 52 patients over a 3-month period. The results continue to support that supplementation with a combination of bioactive molecules (Vitamin D and Beta Glucan) might positively influence the health of individuals with diabetes and other diseases. Leptin levels and C-reactive proteins both were lowered in the Vitamin D and Beta Glucan group. Decreased leptin levels may help to therapeutically influence diabetes. Vitamin D levels increased in all groups, though they were still at a deficit. This suggests that a longer study may need to be initiated.  Read more...

Respiratory (Chronic)Smoking (Passive)

ffects of Transfer Point Glucan #300 Supplementation on Children exposed to Passive Smoking - Placebo-driven Double-blind Clinical Trials

Journal of Nutrition Health 2014 – Article looks at the effects of A.J. Lanigan’s Glucan on children with chronic respiratory infections. There was a marked improvement in overall health of these children as well as increased physical endurance and a reduction of clinical problems.  Read more...

Cancerphagocytosis

Fucoidans Stimulate Immune Reaction and Suppress Cancer Growth

Anticancer Research 2017 —Vetvicka, V. & Vetvickova. Fucoidans Stimulate Immune Reaction and Suppress Cancer growth. 37:6041-6046 (2017)  This article examined the efficacy of fucoidans, complex polysaccharides found predominantly in marine algae, echinoderms and seagrasses, as natural immunomodulators. The study used a variety of fucoidans, both purified samples and commercially available products containing fucoidans. Measures were taken on phagocytosis, mitogenic response, natural killer cell activity, antibody formation and inhibition of breast cancer formation. Results showed that fucoidans have significant biological activities, though the pure fucoidans seemed to have the most activity. The addition of other substances to fucoidans needs to be further studied to determine whether there is any positive effects.  Read more...

ImmunityMelanomaphagocytosis

Glucan Supplementation Has Strong Anti-Melanoma Effects: Role of NK Cells

ANTICANCER RESEARCH 35: 5287-5292 (2015) — “Glucan Supplementation Has Strong Anti-melanoma Effects: Role of NK Cells” – This article looks at the positive effects of beta glucan on melanoma cancer through reduction of tumor weight and lung colonies and improvement of overall survival rate. There was also less damage to blood cells and a potentially increased efficacy of chemotherapy with glucan use.  Read more...

childrenMucosal ImmunityRespiratory (Chronic)

Glucan Supplementation Regulates Secretory Immunity and Stress

American Journal of Immunology 2013 — 5 July 2013- Article looks at effects of Glucan #300 and increased mucosal/salivary immunity in children with chronic respiratory problems.  Read more...

phagocytosisβ-glucan

Glucans and Cancer: Comparison of Commercially Available β-glucans – Part IV

Anticancer Research 2018 —Vetvicka, Vaclav, and Jana Vetvickova. “Glucans and Cancer: Comparison of Commercially Available B-Glucans -Part IV.” Anticancer Research, vol. 38, no. 3, 2018, doi:10.21873/anticanres.12355. This article is a continuation of research on different available Beta Glucans and cancer. Research on the efficacy of Beta Glucan is extensive and may be leading to it becoming a licensed drug in this country. It has stood the test of time, and more and more uses are being identified because of its immunomodulatory properties. More studies to identify the most active Beta Glucans are essential to help consumers. Sixteen different commercial glucans were tested on phagocytosis of peripheral blood neutrophils, inhibition of cancer growth, and as an adjuvant using an experimental model of ovalbumin. These researchers compared these 16 new samples, which included Glucan #300 again, as it had been shown to be the most biologically active sample they had tested in the past tests of 43 samples. In all of the tests this time, and in the past, Glucan #300 was the most active.  Read more...

Heavy MetalsHistory of GlucansRadio‑and ChemotherapyStimulate hematopoiesisStrong Immune Responose

Glucans and Cancer: Historical Perspective

Cancer Transl Med 2015 — Glucans and Cancer: Historical Perspective. The fact that glucans elicit strong and positive immune responses is well‑established. Since the 1980s, we know that glucans stimulate hematopoiesis and are useful before and during radio‑and chemotherapy and during intoxication with heavy metals. In addition, recent years showed that glucans also influence homeostatic processes and can help to neutralize physical, mental, or environmental stress and can help in the treatment of chronic fatigue syndrome.  Read more...

Diabetic RetinopathyInsulinResistenseOrbital DiseaseVitamin D

IgG4-Related Orbital Disease in Patients with Diabetic Retinopathy: Effects of Glucan and Vitamin D Supplementation

Pathology Discovery 2018 - Richter Josef, Závorková Martina, Vetvicka Vaclav*, Král Vlastimil, Stiborova Ivana, Liehneová Ivana and Pohořská Jitka and Rajnohova Dobiasova Lucie. Pathology Discovery, vol. 5, no. 1, 2018, p. 1., doi:10.7243/2052-7896-6-1.  This article again looks at the impact of Beta Glucan when used in conjunction with Vitamin D supplementation on patients identified with Diabetic Retinopathy and Macular Edema, and particularly 7 individuals within that group, who had high levels of IgG4. IgG4 is a subclass of IgG4, which is the most common form of immunoglobulin, which are antibody proteins that are found throughout the body. All 7 individuals were identified through this study to have a probable diagnosis of IgG4ROD (related ophthalmic disease), which involves inflammation, lesions and infiltrates. All the individuals had very low levels of Vitamin D.  The individuals were administered Vitamin D and Transfer Point Beta Glucan over the course of three months. The study reviewed cited past studies with Vitamin D and Beta Glucan, and came to some strong conclusions: Vitamin D is important to mediate the risk of insulin resistance by its effects on insulin receptors; AND “ Functional food supplemented with glucan represents an important perspective not only for treatment, but also for prevention of diabetes mellitus and additional diseases, and possibly leading to reduce(d) healthcare costs and disease prevalence.” They identified that Glucans have a long history in reducing diabetes and insulitis. CONCLUSIONS: Long-term evaluation and beta glucan supplementation, combined with vitamin D supplementation, during general treatment of these patients significantly improved both health and mental conditions. Diabetic Retinopathy is the fifth most common preventable cause of serious vision damage and blindness.  Read more...

MushroomsYeast

Immunlogical Effects of Yeast – and Mushroom-Derived β-Glucans

Med. Food 2008 — Article compares Yeast vs. Mushroom derived beta glucan’s effectiveness on the immune system. Article finds that yeast glucans have a broader immune response in lower doses than mushroom glucans. (A.J. Lanigan’s Beta Glucan is a yeast Glucan).  Read more...

ImmunityVitamin C

Natural Immunomodulators and their Stimulation of Immune Reaction: True or False

Anticancer Research (34) 2014 — Article looks at the effects of 11 commonly used dietary supplements as immunomodulators. The only product with consistently high activity was glucan.  Read more...

phagocytosis

Orally Administered Marine (1 >3)B-D-Glucan Phycarine Stimulates both Humoral and Cellular Immunity

Int. J. Biol. Macromol. 2007 — Article shows that Beta 1,3 Glucans, in addition to enhancing the immune system, enhances the effects of chemo-therapy drugs and prevents or reverses their negative effects on the immune system. Also, article discusses the uptake of glucans in the gut.  Read more...

Blood Glucosecholesterol

PHYSIOLOGICAL EFFECTS OF DIFFERENT TYPES OF β-GLUCAN

Biomed Pap Med 2007 — Article shows A.J. Lanigan’s Beta 1, 3-D Glucan is not only a highly effective broad response immune modulator but is also effective in lowering blood cholesterol and blood glucose levels. Conclusion: Taken together, our study showed that with respect to natural glucans, there is a yes-or-no effect suggesting that highly purified and highly active glucans will have pleiotropic impact, whereas poorly isolated and/or less active glucans will have only mediocre biological properties.  Read more...

AnthraxChemotherapyInfectionRadiationTumors

Pilot Study: Orally-Administered Yeast β β1,3-glucan Prophylactically Protects Against Anthrax Infection and Cancer in Mice

JANA Spring 2002 — Article summarizes research showing beta glucans are effective against anthrax, cancer tumors and is beneficial in chemotherapy and radiation recovery. JANA Spring 2002 Pilot Study: Orally-Administered Yeast β β1,3-glucan prophylactically protects against anthrax Infection and cancer in Mice.  Read more...

childrenImmunityMucosal ImmunityPhysical Stress

Placebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children with Chronic Respiratory Problems: Antibody Production

American Journal of Immunology  5 July 2013- Article looks at effects of Glucan #300 and increased mucosal/salivary immunity in children with chronic respiratory problems.  Read more...  

childrenMucosal Immunity

Placebo-Driven Clinical Trials of Yeast-Derived β -(1,3) Glucan in Children with Chronic Respiratory Problems

Annals of Translation Medicine — 1 July 2013- Article looks at the effects of Glucan in CHILDREN with CHRONIC RESPIRATORY PROBLEMS and its potential ability to stimulate mucosal immunity in C-reactive protein and lysozyme.  Read more...

ObesityRadio‑and Chemotherapy`

Reconstruction of Natural Killer (NK) Cells During Complex Cancer Treatment

Journal of Tumor 2016 — A randomized, double-blind, placebo-controlled trial compared β-glucan #300 and a placebo in people after complex surgical, radiation and/or chemotherapy treatment of cancer. Starting points of cancer disease are closely associated with obesity. The role of glucan in potentiation of immune system is well established, including effects on cancer development. In this study, we focused on effects of short term glucan supplementation in patients during complex cancer treatment. Our findings show the significant effects of glucan supplementation on induction of NK cell, suggesting that addition of glucan to the diet could be beneficial for prevention of cancer remission. The glucan-supplemented group exhibited some improvements in psychic conditions, nutritional state and overall feeling of well-being. Longer supplementation seems to be necessary. CONCLUSIONS: Our findings show the significant effects of glucan supplementation on induction of NK cell, suggesting that addition of glucan to the diet could be beneficial for prevention of cancer remission. The glucan-supplemented group exhibited some improvements in psychic conditions, nutritional state and overall feeling of well-being. Longer supplementation seems to be necessary.  Read more...

Natural Killer Cells (NK)Tumor Immunity

Regulation of CR3 (CD11b/CD18) Dependent Natural Killer (NK) Cell Cytotoxicity by Tumour Target Cell MHC class I Molecules

Clin. Exp. Immunol. 1999 — Article demonstrates that beta glucan’s CR3 binding properties can be effective against cancer tumor cells that do not have CR3 receptor sites by potentiating natural killer (NK) cells to see the tumor cells as non-self.  Read more...

AnemiaHematopoieses

Regulation of Hematopoiesis in Cancer Patients: Placebo Driven, Double-Blind Clinical Trials of β-Glucan

Journal of Tumor 2015 – “Regulation of Hematopoiesis in Cancer Patients: Placebo-Driven, Double-Blind Clinical Trials of β-Glucan.”- This article focuses on the effects of glucan supplementation on cancer patients in post-treatment periods to try to alleviate anemia. There was significant improvement in hemoglobin counts and erythrocytes. This article explores the efficacy of beta glucan for improving the after-effects of cancer therapies. One major side effect of cancer and its treatments is anemia. “Hematopoiesis is the production of all types of blood cells including formation, development, and differentiation of blood cells. Prenatally, hematopoiesis occurs in the yolk sack, then in the liver, and lastly in the bone marrow. In the normal situation, hematopoiesis in adults occurs in the bone marrow and lymphatic tissues.” (Medicinenet.com) More than 50% of cancer patients end up with anemia. This impacts their immune systems, their quality of life and their survival rates. Anemia can make the cells in our bodies not get enough oxygen. Sometimes, a lack of oxygen may be severe enough to threaten people’s life. Anemia can also cause our hearts to work harder. Severe anemia can cause a delay in cancer treatments or make the treatment dose be reduced. It can also cause some treatments to not work as well as they should. Cancer can cause anemia in many different ways. Normally, the kidneys send hormones to the bone marrow signal for it to produce red blood cells. This process can be disrupted by cancer slowing the hormone production or by not allowing the body to use stored iron. Red blood cells also wear out faster than normal in cancer patients and may not be replaced as quickly as they are needed. Fewer red blood cells means there is less hemoglobin carrying oxygen throughout your body and hence, the immune system and everything else gets compromised. This study showed,” The addition of glucan to the food during cancer increased chemotaxis and adhesion of neutrophils, affected the production of myeloid growth factors resulting in increase of hematopoiesis and influenced peripheral progenitors cells in the blood. In a model of irradiated mice, glucan caused regeneration of hematopoiesis and increased survival. In addition, some studies showed a direct increase in the destruction of tumor cells and higher tumoricidal activity by glucan treatment.” (Vetvicka 2015) The study also looked at anemia and chronic fatigue syndrome.  CONCLUSIONS: We concluded that the short 60-day supplementation with orally-administered glucan significantly improved some parameters of hematopoiesis.  Read more...  

Natural Killer (NK) CellsProstate specific antigen (PSA)Tumor Immunity

Therapeutic intervention with complement and B-Glucan in cancer

Pathology Discovery – 2014 – Volume 2/Article 8 — Article researches the effects of oral beta glucan on benign prostate hyperplasia. Initial findings show an improvement of NK cell numbers and positive effects on the PSA indices. Further support is provided by way of a case study report. CONCLUSIONS:  Our study offers preliminary results supporting the hypothesis that oral administration of glucan has positive effects in patients suffering from benign prostate hyperplasia. Our conclusion is supported by the case report showing significant effects with longer supplementation and higher dose.  Read more...

CytokinesImmunomodulatorsImmunotherapyTumor Immunity

Therapeutic intervention with complement and β-Glucan in Cancer

Ross Immunopharmacology 1999 — Article details beta Glucans mode of action on the immune system. Article describes how CR3 binding by beta Glucan begins a broad immune response especially to cancer tumor cells which the immune system might ordinarily only partially target.   Read more..

AtherogenesisCardiovascular Diseases Weight losscholesterolDecrease LeptinDiabetic Retinopathy NutritionNatural Killer Cells

Vitamin D and Β-Glucan Supplementation Affects Levels of Leptin, Apolipoproteins And General Nutrition State In Patients with Diabetic Retinopathy

Edorium J Pathol 2018 - Vitamin D and β-glucan supplementation affects levels of leptin, apolipoproteins and general nutrition state in patients with diabetic retinopathy. Glucan also plays an important role in cholesterol regulation, probably via interaction with lipids and biliary salt in the bowel [28]. β-glucan supplementation results in significant risk reduction of atherogenesis and cardiovascular diseases [6, 7, 19, 20]. Also important is the significant weight decrease in Group A patients, which correlated with decrease of leptin (linear regression leptin/BMI is P <0.0014). The fact that leptin plays an important role in homeostatic regulation of energy is well established, and attention is currently focused on its role in glycemia control. These new findings suggest using leptin as supplement in diabetes treatment [15]. Based on our data, we suggest that simultaneous use of β-glucan and vitamin D might be used in complex treatment of diabetic retinopathy [29].  Read more...

Inflammation

β(1-3)-D-Glucan Affects Adipogenesis, Wound Healing and Inflammation

Oriental Pharm Exp Med- 30 July 2011 — Article supports that Glucan #300 is superior at supporting wound healing and lowering skin irritation and inflammation. Oriental Pharm Exp Med- 30 July 2011 β(1-3)-D-Glucan affects adipogenesis, wound healing and inflammation.  Read more...  

childrenMucosal ImmunityRespiratory (Chronic)

β-Glucan Affects Mucosal Immunity in Children with Chronic Respiratory Problems Under Physical Stress: Clinical Trials

Annals of Translational Medicine 2015 – Josef Richter, Vladimir Svozil, Vlastimil Král, Lucie Rajnohová Dobiášová, Vaclav Vetvicka – a randomized, double-blind, placebo-controlled trial compared β-glucan and a placebo in children. β-glucan affects mucosal immunity in children with chronic respiratory problems under physical stress: clinical trials.  Read more...    

AllergyAnti-Cancer ImmunityAnti-InfectiousArthritisGastrointestinal tract diseasesReduction Cholesterol LevevlsStress reduction

β-Glucan – from Food Supplement to a Licensed Drug

J Cell Sci Ther 2015 - β-Glucan – from Food Supplement to a Licensed Drug.  CONCLUSION:  All these new findings mentioned above open the window for β-glucan to become a licensed drug. In addition to effects in anti-infectious and anti-cancer immunity, novel studies clearly demonstrated significant palliative effects of β-glucan in allergy, arthritis, gastrointestinal tract diseases, stress reduction and reduction of cholesterol levels (for review see [5]). With over 60 clinical trials currently running, the question of whether other countries will follow Japan, where β-glucan is officially used since 1983, is not if, but when.  Read more...

Immune Systemnutrition

β-Glucan – Is the Current Research Relevant?

International Clinical Pathology Journal 2017 —Vetvicka, Vaclav, and Jana Vetvickova. “Β-Glucan – Is the Current Research Relevant?”. International Clinical Pathology Journal4.2 (2017): 89.  This article focuses on the need for more research with Beta Glucan both on animals and humans. The authors discuss the known benefits of B Glucan, such as phagocytosis and macrophages and cytokines, and suggest that there could be many more valuable uses. To this end, they support increased research into “a wider spectrum” of immune reactions. Science is supporting improved nutrition to help fight cancer, and B Glucan could be valuable in this arena.  Read more...

Natural Killer (NK) Cells

β-Glucan, a “Specific” Biologic Response Modifier That Uses Antibodies to Target Tumors for Cytotoxic Recognition by Leukocyte Complement Receptor Type 3 (CD11b/CD18)

Yan J Immunol 1999 — Article shows that beta glucan enhances tumor targeting by immune cells when used with certain antibodies. Article also describes beta glucan’s role in  (modifying) cancer tumor cells with an iC3b molecule causing immune cells to target those tumor cells which may otherwise not be attacked.  Read more...